CBMC Primary Faculty
Ken Bastow, PhD
- Associate Professor
Design and development of topoisomerase inhibitors/ antiviral chemotherapy
Stephen Frye, PhD
- Professor
- Director, Center for Integrative Chemical Biology and Drug Discovery
Drug design, enzyme inhibitor design, protein kinases
Michael Jarstfer, PhD
- Associate Professor
- Division Director of Graduate Studies
Synthetic chemistry, molecular biology, and combinatorial chemistry techniques are used to investigate the ribonucleoprotein telomerase, which plays a pivotal role in tumorgenesis.
Harold Kohn, PhD
- Kenan Distinguished Professor
Examination of the biological mechanism of mitomycin C and bicyclomycin at the molecular level; design and synthesis of new chemotherapeutic agents for the treatment of epilepsy, cancer, and bacterial infections
David Lawrence, PhD
- Fred Eshelman Distinguished Professor
- Chair, Division of Chemical Biology and Medicinal Chemistry
Inhibitors and drug development; enzyme sensors; light-activated inhibitors, sensors, and signaling proteins; light-induced gene expression; chemical genomics
Andrew Lee, PhD
- Associate Professor
- Division Director of Graduate Admissions
Using NMR spectroscopy to study the relationship between protein structure and dynamics and how these respond to perturbations such as binding (natural ligands or drugs) and mutation (evolution).
Kuo-Hsiung Lee, PhD
- Kenan Distinguished Professor of Medicinal Chemistry
- Director of Natural Products Research Laboratories
Medicinal chemistry, bioactive natural products, new drug discovery and development, and Chinese medicine.
Jian Liu, PhD
- Professor
Identification of polysaccharide-based receptor; structure and specificity of a heparan sulfate-based herpes simplex virus 1 receptor; drug targeting; gene therapy.
Rihe Liu, PhD
- Associate Professor
Functional proteomics approaches to defining protein-protein interaction networks, identifying enzyme-substrate and drug-protein target interactions at a proteome-wide scale, and screening for antibody-like affinity molecules for biomarkers using in vitro protein selection technology
Bryan Roth, PhD, MD
- Professor
- Director, NIMH Psychoactive Drug Screening Program
G-protein coupled receptors structure and function ranging from the atomic-level analysis of ligand-receptor interactions to in vivo studies.
Scott F. Singleton, PhD
- Associate Professor
- Division Vice Chair
Bio-organic and biophysical chemical investigations of the mechanisms of DNA repair, directed evolution of novel enzymes, and development of alternate strategies for targeting drug-resistant pathogenic microorganisms.
Alexander Tropsha, PhD
- Associate Dean for Research
- K. H. Lee Distinguished Professor
Development of new methodologies and software tools for computer-assisted drug design; Development of new approach to protein 3D structure analysis and prediction based on the principles of statistical geometry
Qisheng Zhang, PhD
- Assistant Professor
Studying endogenous, small molecule-protein interactions and their downstream signaling
