Kim L.R. Brouwer, Pharm.D., Ph.D., is the William R. Kenan Jr. Distinguished Professor in the Division of Pharmacotherapy and Experimental Therapeutics of the UNC Eshelman School of Pharmacy, associate dean for research and graduate education, and a professor in the curriculum in toxicology.
Brouwer received her B.S. in pharmacy from Oregon State University. Brouwer completed her Pharm.D. at the University of Kentucky College of Pharmacy in conjunction with a pharmacy residency at the UK Medical Center and a PhD in pharmaceutical sciences/pharmacokinetics. After postdoctoral training (pharmacology/drug metabolism) in the UK College of Medicine, she joined the faculty at the University of North Carolina in 1986 where she served as director of graduate studies for the UNC Eshelman School of Pharmacy from 1996 to 2004.
Brouwer directs an NIH-funded research program focused on hepatobiliary drug disposition and development and refinement of in vitro model systems to predict in vivo hepatobiliary disposition, drug interactions, and hepatotoxicity. She has mentored more than 85 undergraduate, graduate and postdoctoral students and published more than 295 research papers, abstracts and book chapters.
Brouwer is a co-inventor of B-CLEAR® (U.S. Patent No. 6,780,580), an in vitro method to assess hepatic uptake, excretion, and biliary clearance that correlates with in vivo data. This technology has been exclusively licensed from the University of North Carolina at Chapel Hill to Qualyst, Inc. Brouwer is a Qualyst founder and chairs the company’s scientific advisory board.
She served as a member of the NIH Pharmacology Study Section from 1998 to 2002 and is a member of the editorial boards for Drug Metabolism and Disposition, Clinical Pharmacology and Therapeutics and the AAPS Journal. She was elected an AAPS Fellow in 1998, was recipient of the PHRMA Foundation Award in Excellence in Pharmaceutics in 2001 and received the inaugural Pharmaceutical Sciences Outstanding Graduate Program Alumni Award and the Paul F. Parker Award from the University of Kentucky.
- Mechanisms of hepatic uptake, translocation and biliary excretion
- Drug transport
- Aberrant gastrointestinal drug absorption phenomena
- Ph.D., University of Kentucky
- Pharm.D., University of Kentucky
- B.S., Oregon State University