click to enlargeXiaoming Yang, PhD
Research synopsis:
Preclinical studies on a family of natural products phenanthroindolizidines and phenanthroquinolizidines such as tylophorine, antofine, and cryptopleurine analogs as potential drugs for treating lung, colon, and breast cancer. Total synthesis of complex natural molecules that have interesting anticancer activity and development of such therapeutic agents into clinical trials.
Selected publications:
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1. |
Yang, X.; Shi, Q.; Liu, Y. N.; Zhao, G.; Bastow, K. F.; Lin, J. C.; Yang, S. C.; Yang, P. C.; Lee, K. H. Antitumor agents 268. Design, Synthesis, and Mechanistic Studies of New 9-Substituted Phenanthrene-based Tylophorine Analogues as Potent Cytotoxic Agents. J. Med. Chem. 2009, 52, 5262-5268. |
2.Yang, X.; Shi, Q.; Bastow, K. F.; Lee, K. H. Antitumor Agents 274. A New Synthetic Strategy for E-ring SAR Study of Antofine and Cryptopleurine Analogs. Org. Lett. 2010, 12, 1416-1419.
3.Yang, X.; Shi, Q.; Yang, S. C.; Chen, C. Y.; Yu, S. L.; Bastow, K. F.; Morris-Natschke, S. L.; Wu, P. C.; Lai, C. Y.; Wu, T. S.; Pan, S. L.; Teng, C. M.; Lin, J. C.; Yang, P. C.; Lee, K. H. Antitumor Agents 288. Design, Synthesis, SAR, and Biological Studies of Novel Heteroatom-Incorporated Antofine and Cryptopleurine Analogs as Potent and Selective Antitumor Agents. J. Med. Chem. 2011, 54, 5097-5107.
