EDUCATION

Ph.D. Organic Chemistry August 1982; University of North Carolina-Chapel Hill

     Advisor: Dr. Ernest L. Eliel

     Dissertation: Stereoselective Reactions of 2-Acyl-1,3-oxathianes

     with Grignard and Other Organometallic Reagents

B.S. Chemistry May 1975; University of Maryland-College Park

RESEARCH SYNOPSIS

Dr. Morris-Natschke writes and edits all forms of publications including peer-reviewed journal articles, book chapters and reviews, grant proposals to government, industry, and private foundations, as well as patent applications.  She also interacts directly with outside collaborators, including scientific, administrative, and legal representatives to coordinate and clarify research, grant, and patent issues.  As a medicinal chemistry instructor in graduate and professional-level courses, she has lectured on β-lactam antibiotics, natural products chemistry (steroids, alkaloids), alternative medicine and herbal drugs, proposal writing, and phospholipids, among other topics.

SELECT PUBLICATIONS from over 110 published journal articles and book chapters, as well as 16 US patents.

1. Dong, Y.; Morris-Natschke, S.L.; Lee, K.H. Biosynthesis, Total Syntheses, and Antitumor Activity of Tanshinones and Their Analogs as Potential Therapeutic Agents. Nat. Prod. Rep., 28, 529-542 (2011). 
2. Qian, K.; Nitz, T.J.; Yu, D.; Allaway, G.P.; Morris-Natschke, S.L.; Lee, K.H. From Natural Product to Clinical Trials: Bevirimat, a Plant-derived Anti-AIDS Drug, In Natural Product Chemistry for Drug Discovery, Royal Society of Chemistry, Cambridge, UK. 2010, pp 374-391.
3. Kuo, R.Y.; Qian, K.; Morris-Natschke, S.L.; Lee, K.H. Plant-derived Triterpenoids and Analogues as Antitumor and Anti-HIV Agents. Nat. Prod. Rep., 26, 1321-1344 (2009).
4. Itokawa, H.; Morris-Natschke, S.L.; Akiyama, T.; Lee, K.H. Antitumor Agents 263 and Anti-AIDS Agents 74. Plant-Derived Natural Products Research Aimed at New Drug Discovery. Nat. Med., 62, 263-280 (2008).
5. Yu, D.; Morris-Natschke, S.L.; Lee, K.H. New Developments in Natural Products-based Anti-AIDS Research. Med. Res. Rev., 27, 108-32 (2007).
6. Morris-Natschke, S.L.; Ishaq, K.S.; Kucera, L.S. Phospholipid Analogs Against HIV-1 Infection and Disease. Curr. Pharm. Des., 9, 1441-51 (2003).
7. Modest, E.J.; Daniel, L.W.; Wykle, R.L.; Piantadosi, C.; Surles, J.R.; Morris-Natschke, S. Novel Phospholipid Analogs as Membrane-Active Antitumor Agents, In 8th Annual Bristol-Myers Symposium on Cancer Research: New Avenues in Developmental Cancer Chemotherapy, London, England, Chapter 19, pp. 387-400 (1986).
8. Eliel, E.L.; Koskimies, J.K.; Lohri, B.L.; Frazee, W.J.; Morris-Natschke, S.; Lynch, J.E.; Soai, K. Asymmetric Synthesis of Chiral Tertiary Alcohols in High Enantiomeric Excess, In Asymmetric Reactions and Processes in Chemistry, ACS Symposium Series No. 185, Washington, DC, 1982, pp. 37-53.