Mary Paine, PhD
- Registered Pharmacist
Mary Paine, PhD, practiced for four years as a hospital pharmacist before entering the graduate program in the Department of Pharmaceutics at the University of Washington. She is a licensed pharmacist. After receiving her PhD, she completed a postdoctoral fellowship at the University of Michigan Medical Center, where she focused on the use of human-intestine-derived in vitro systems as models to evaluate the influence of various enteric drug metabolizing enzymes and transporters on drug disposition. Paine first became affiliated with the UNC Eshelman School of Pharmacy in 1999, when she assumed a position as director of a translational research laboratory in the UNC General Clinical Research Center. During this time, she mentored a number of postdoctoral and graduate students and focused on establishing herself as an independent investigator in the relatively understudied area of the effects of dietary substances on drug disposition. Simultaneously, through interactions with colleagues in medicine and pharmacy, Paine became interested in the pharmacokinetics and toxicokinetics of new drug candidates for the treatment of neglected tropical diseases, including visceral leishmaniasis and African sleeping sickness.
The Paine Lab is applying a translational research approach, guided by pharmacokinetic and pharmacodynamic modeling and simulation, to address real-world challenges. Specifically, they are developing novel methodologies to evaluate drug-dietary substance and herbal-supplement interactions prospectively. The lab is also advancing the development of promising orally-active antiparasitic agents for treatment of African sleeping sickness.